4PUB

Crystal structure of Fab DX-2930

Summary for 4PUB

• Entry DOI: 10.2210/pdb4pub/pdb
• Related: 4ogx 4ogy
• Descriptor: DX-2930 HEAVY CHAIN, DX-2930 LIGHT CHAIN, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: fab, antibody, kallikrein, blood, plasma, plasma kallikrein-mediated edema, acute hereditary angioedema, hae, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 47520.60

Authors

Abendroth, J.,Edwards, T.E.,Nixon, A.,Ladner, R. (deposition date: 2014-03-12, release date: 2014-07-09, Last modification date: 2023-09-20)

• Primary citation: Kenniston, J.A.,Faucette, R.R.,Martik, D.,Comeau, S.R.,Lindberg, A.P.,Kopacz, K.J.,Conley, G.P.,Chen, J.,Viswanathan, M.,Kastrapeli, N.,Cosic, J.,Mason, S.,DiLeo, M.,Abendroth, J.,Kuzmic, P.,Ladner, R.C.,Edwards, T.E.,TenHoor, C.,Adelman, B.A.,Nixon, A.E.,Sexton, D.J.; Inhibition of plasma kallikrein by a highly specific active site blocking antibody.; J.Biol.Chem., 289:23596-23608, 2014; PubMed: 24970892; DOI: 10.1074/jbc.M114.569061

Experimental method

X-RAY DIFFRACTION (1.75 Å)