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4PS5

Crystal structure of the first bromodomain of human BRD4 in complex with TG101348

Replaces:  4O73
Summary for 4PS5
Entry DOI10.2210/pdb4ps5/pdb
DescriptorBromodomain-containing protein 4, N-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywordsbromodomain, cap, hunk1, mcap, protein binding-inhibitor complex, mitotic chromosome associated protein, cell cycle, inhibitor, transcription-inhibitor complex, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total formula weight31493.36
Authors
Ember, S.W.,Zhu, J.-Y.,Watts, C.,Schonbrunn, E. (deposition date: 2014-03-06, release date: 2014-03-19, Last modification date: 2023-09-20)
Primary citationEmber, S.W.,Zhu, J.Y.,Olesen, S.H.,Martin, M.P.,Becker, A.,Berndt, N.,Georg, G.I.,Schonbrunn, E.
Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors.
Acs Chem.Biol., 9:1160-1171, 2014
Cited by
PubMed: 24568369
DOI: 10.1021/cb500072z
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.4 Å)
Structure validation

217705

數據於2024-03-27公開中

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