4PS5

Crystal structure of the first bromodomain of human BRD4 in complex with TG101348

「4O73」から置き換えられました

4PS5 の概要

• エントリーDOI: 10.2210/pdb4ps5/pdb
• 分子名称: Bromodomain-containing protein 4, N-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: bromodomain, cap, hunk1, mcap, protein binding-inhibitor complex, mitotic chromosome associated protein, cell cycle, inhibitor, transcription-inhibitor complex, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 31493.36

構造登録者

Ember, S.W.,Zhu, J.-Y.,Watts, C.,Schonbrunn, E. (登録日: 2014-03-06, 公開日: 2014-03-19, 最終更新日: 2023-09-20)

• 主引用文献: Ember, S.W.,Zhu, J.Y.,Olesen, S.H.,Martin, M.P.,Becker, A.,Berndt, N.,Georg, G.I.,Schonbrunn, E.; Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors.; Acs Chem.Biol., 9:1160-1171, 2014; PubMed: 24568369; DOI: 10.1021/cb500072z

実験手法

X-RAY DIFFRACTION (1.4 Å)