4PRG

0072 PARTIAL AGONIST PPAR GAMMA COCRYSTAL

4PRG の概要

• エントリーDOI: 10.2210/pdb4prg/pdb
• 分子名称: PROTEIN (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA), (+/-)(2S,5S)-3-(4-(4-CARBOXYPHENYL)BUTYL)-2-HEPTYL-4-OXO-5-THIAZOLIDINE (2 entities in total)
• 機能のキーワード: thiazolidinone, ligand-binding domain, nuclear receptor, orphan receptor, receptor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 125794.75

構造登録者

Milburn, M.V. (登録日: 1999-05-07, 公開日: 1999-05-27, 最終更新日: 2023-12-27)

• 主引用文献: Oberfield, J.L.,Collins, J.L.,Holmes, C.P.,Goreham, D.M.,Cooper, J.P.,Cobb, J.E.,Lenhard, J.M.,Hull-Ryde, E.A.,Mohr, C.P.,Blanchard, S.G.,Parks, D.J.,Moore, L.B.,Lehmann, J.M.,Plunket, K.,Miller, A.B.,Milburn, M.V.,Kliewer, S.A.,Willson, T.M.; A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation.; Proc.Natl.Acad.Sci.USA, 96:6102-6106, 1999; PubMed: 10339548; DOI: 10.1073/pnas.96.11.6102

実験手法

X-RAY DIFFRACTION (2.9 Å)