4PR4
Human Aldose Reductase complexed with Schl7802 at 1.06 A
Summary for 4PR4
Entry DOI | 10.2210/pdb4pr4/pdb |
Related | 2IKG 2IKH 3DN5 4NKC |
Descriptor | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-(3'-nitrobiphenyl-3-yl)propanoic acid, ... (4 entities in total) |
Functional Keywords | tim barrel, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 36781.82 |
Authors | Rechlin, C.,Heine, A.,Klebe, G. (deposition date: 2014-03-05, release date: 2015-04-08, Last modification date: 2023-09-20) |
Primary citation | Rechlin, C.,Heine, A.,Ortmann, R.,Schlitzer, M.,Klebe, G. Keys to open the specificity pocket: Biphenylic Inhibitors of the human aldose reductase To be Published, |
Experimental method | X-RAY DIFFRACTION (1.06 Å) |
Structure validation
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