4PQW

Crystal Structure of Phospholipase C beta 3 in Complex with PDZ1 of NHERF1

Summary for 4PQW

Entry DOI	10.2210/pdb4pqw/pdb
Descriptor	Na(+)/H(+) exchange regulatory cofactor NHE-RF1, CHLORIDE ION, NICKEL (II) ION, ... (4 entities in total)
Functional Keywords	nherf1, plcb3, scaffold protein, pancreatic cancer, protein binding
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm (By similarity): O14745
Total number of polymer chains	1
Total formula weight	10142.88
Authors	Jiang, Y.,Wang, S.,Holcomb, J.,Trescott, L.,Guan, X.,Hou, Y.,Brunzelle, J.,Sirinupong, N.,Li, C.,Yang, Z. (deposition date: 2014-03-04, release date: 2014-04-02, Last modification date: 2023-09-20)
Primary citation	Jiang, Y.,Wang, S.,Holcomb, J.,Trescott, L.,Guan, X.,Hou, Y.,Brunzelle, J.,Sirinupong, N.,Li, C.,Yang, Z. Crystallographic analysis of NHERF1-PLC beta 3 interaction provides structural basis for CXCR2 signaling in pancreatic cancer. Biochem.Biophys.Res.Commun., 446:638-643, 2014 Cited by PubMed: 24642259 DOI: 10.1016/j.bbrc.2014.03.028 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.47 Å)

Structure validation