4POY

Engineered Dual Specific VHH antibody

4POY の概要

• エントリーDOI: 10.2210/pdb4poy/pdb
• 関連するPDBエントリー: 4POU
• 分子名称: VHH-metal (2 entities in total)
• 機能のキーワード: single domain antibody, vhh, metalloregulation, bispecific, dual-function, protein engineering, affinity control, protein-switch, antibody engineering, nickel binding protein, protein-metal coordination geometry, loop dynamics, protein flexibility, conformational dynamics, binding thermodynamics, antibody-metal complex, immune system
• 由来する生物種: Lama glama
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12941.36

構造登録者

Fanning, S.W.,Walter, R.,Horn, J.R. (登録日: 2014-02-26, 公開日: 2014-09-24, 最終更新日: 2014-10-22)

• 主引用文献: Fanning, S.W.,Walter, R.,Horn, J.R.; Structural basis of an engineered dual-specific antibody: conformational diversity leads to a hypervariable loop metal-binding site.; Protein Eng.Des.Sel., 27:391-397, 2014; PubMed: 25143596; DOI: 10.1093/protein/gzu033

実験手法

X-RAY DIFFRACTION (1.5 Å)