4POV

ThiT with LMG135 bound

Summary for 4POV

• Entry DOI: 10.2210/pdb4pov/pdb
• Related: 3RLB 4POP
• Descriptor: Thiamine transporter ThiT, CHLORIDE ION, 4-[(4-amino-2-methylpyrimidin-5-yl)methyl]-3-methylthiophene-2-carbaldehyde, ... (11 entities in total)
• Functional Keywords: s-component, thiamine-binding protein, ecf module, membrane, protein binding
• Biological source: Lactococcus lactis subsp. cremoris
• Cellular location: Cell membrane ; Multi-pass membrane protein : A2RI47
• Total number of polymer chains: 2
• Total formula weight: 49328.63

Authors

Swier, L.J.Y.M.,Guskov, A.,Slotboom, D.J. (deposition date: 2014-02-26, release date: 2014-09-17, Last modification date: 2023-09-20)

• Primary citation: Swier, L.J.,Monjas, L.,Guskov, A.,de Voogd, A.R.,Erkens, G.B.,Slotboom, D.J.,Hirsch, A.K.; Structure-Based Design of Potent Small-Molecule Binders to the S-Component of the ECF Transporter for Thiamine.; Chembiochem, 16:819-826, 2015; PubMed: 25676607; DOI: 10.1002/cbic.201402673

Experimental method

X-RAY DIFFRACTION (2.2 Å)