4PNC

E. COLI METHIONINE AMINOPEPTIDASE IN COMPLEX WITH INHIBITOR 7-METHOXY-2-METHYLEN-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE

Summary for 4PNC

Entry DOI	10.2210/pdb4pnc/pdb
Related	1XNZ 1YVM 3MAT
Descriptor	Methionine aminopeptidase, (2S)-7-methoxy-2-methyl-3,4-dihydronaphthalen-1(2H)-one, COBALT (II) ION, ... (5 entities in total)
Functional Keywords	hydrolase(alpha-aminoacylpeptide), metal complex, methionine aminopeptidase, covalent inhibitor, 1-tetralone, hydrolase
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	29731.80
Authors	Scheidig, A.J.,Altmeyer, M.,Klein, C.D. (deposition date: 2014-05-23, release date: 2014-07-23, Last modification date: 2023-12-27)
Primary citation	Altmeyer, M.,Amtmann, E.,Heyl, C.,Marschner, A.,Scheidig, A.J.,Klein, C.D. Beta-aminoketones as prodrugs for selective irreversible inhibitors of type-1 methionine aminopeptidases. Bioorg.Med.Chem.Lett., 24:5310-5314, 2014 Cited by PubMed: 25293447 DOI: 10.1016/j.bmcl.2014.09.047 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.54 Å)

Structure validation