4PNC
E. COLI METHIONINE AMINOPEPTIDASE IN COMPLEX WITH INHIBITOR 7-METHOXY-2-METHYLEN-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE
Summary for 4PNC
Entry DOI | 10.2210/pdb4pnc/pdb |
Related | 1XNZ 1YVM 3MAT |
Descriptor | Methionine aminopeptidase, (2S)-7-methoxy-2-methyl-3,4-dihydronaphthalen-1(2H)-one, COBALT (II) ION, ... (5 entities in total) |
Functional Keywords | hydrolase(alpha-aminoacylpeptide), metal complex, methionine aminopeptidase, covalent inhibitor, 1-tetralone, hydrolase |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 29731.80 |
Authors | Scheidig, A.J.,Altmeyer, M.,Klein, C.D. (deposition date: 2014-05-23, release date: 2014-07-23, Last modification date: 2023-12-27) |
Primary citation | Altmeyer, M.,Amtmann, E.,Heyl, C.,Marschner, A.,Scheidig, A.J.,Klein, C.D. Beta-aminoketones as prodrugs for selective irreversible inhibitors of type-1 methionine aminopeptidases. Bioorg.Med.Chem.Lett., 24:5310-5314, 2014 Cited by PubMed: 25293447DOI: 10.1016/j.bmcl.2014.09.047 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.54 Å) |
Structure validation
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