4PM0
PDE7A catalytic domain in complex with 2-(Cyclopentylamino)thieno[3,2-d]pyrimidin-4(3H)-one derivative
Summary for 4PM0
Entry DOI | 10.2210/pdb4pm0/pdb |
Descriptor | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | phosphodiesterase, pde7, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Isoform PDE7A1: Cytoplasm, cytosol. Isoform PDE7A2: Cytoplasm: Q13946 |
Total number of polymer chains | 1 |
Total formula weight | 44876.23 |
Authors | Kawai, K.,Endo, Y.,Asano, T.,Amano, S.,Sawada, K.,Ueo, N.,Takahashi, N.,Sonoda, Y.,Kamei, N.,Nagata, N. (deposition date: 2014-05-20, release date: 2014-12-03, Last modification date: 2023-11-08) |
Primary citation | Kawai, K.,Endo, Y.,Asano, T.,Amano, S.,Sawada, K.,Ueo, N.,Takahashi, N.,Sonoda, Y.,Nagai, M.,Kamei, N.,Nagata, N. Discovery of 2-(Cyclopentylamino)thieno[3,2-d]pyrimidin-4(3H)-one Derivatives as a New Series of Potent Phosphodiesterase 7 Inhibitors. J.Med.Chem., 57:9844-9854, 2014 Cited by PubMed: 25383422DOI: 10.1021/jm5008215 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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