4PIV

Human Fatty Acid Synthase Psi/KR Tri-Domain with NADPH and GSK2194069

4PIV の概要

• エントリーDOI: 10.2210/pdb4piv/pdb
• 分子名称: Fatty acid synthase, CACODYLATE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total)
• 機能のキーワード: fatty acid synthase, human fas, keto-reductase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 146702.41

構造登録者

Williams, S.P.,Wang, L.,Brown, K.K.,Parrish, C.A.,Hardwicke, M.A. (登録日: 2014-05-09, 公開日: 2014-07-23, 最終更新日: 2023-12-27)

• 主引用文献: Hardwicke, M.A.,Rendina, A.R.,Williams, S.P.,Moore, M.L.,Wang, L.,Krueger, J.A.,Plant, R.N.,Totoritis, R.D.,Zhang, G.,Briand, J.,Burkhart, W.A.,Brown, K.K.,Parrish, C.A.; A human fatty acid synthase inhibitor binds beta-ketoacyl reductase in the keto-substrate site.; Nat.Chem.Biol., 10:774-779, 2014; PubMed: 25086508; DOI: 10.1038/nchembio.1603

実験手法

X-RAY DIFFRACTION (2.299 Å)