4PH9
The structure of Ibuprofen bound to cyclooxygenase-2
Summary for 4PH9
Entry DOI | 10.2210/pdb4ph9/pdb |
Related | 1EQG 3HS5 3NT1 3QMO |
Descriptor | Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total) |
Functional Keywords | membrane protein, cyclooxygenase, cox, cox-2, ibuprofen, monotopic, prostaglandin, nsaid, oxidoreductase |
Biological source | Mus musculus (Mouse) |
Total number of polymer chains | 2 |
Total formula weight | 132637.56 |
Authors | Orlando, B.J.,Lucido, M.J.,Malkowski, M.G. (deposition date: 2014-05-05, release date: 2014-11-26, Last modification date: 2023-09-27) |
Primary citation | Orlando, B.J.,Lucido, M.J.,Malkowski, M.G. The structure of ibuprofen bound to cyclooxygenase-2. J.Struct.Biol., 189:62-66, 2015 Cited by PubMed: 25463020DOI: 10.1016/j.jsb.2014.11.005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.81 Å) |
Structure validation
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