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4PF7

Crystal structure of insulin degrading enzyme complexed with inhibitor

Summary for 4PF7
Entry DOI10.2210/pdb4pf7/pdb
Related4PF9 4PFC
DescriptorInsulin-degrading enzyme, (2S)-2-amino-N-{(1S)-1-cyclohexyl-2-[(4-methylphenyl)amino]-2-oxoethyl}-4-(methylselanyl)butanamide, ZINC ION, ... (4 entities in total)
Functional Keywordshydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: P14735
Total number of polymer chains2
Total formula weight229966.66
Authors
Wang, Y.,Guo, S. (deposition date: 2014-04-28, release date: 2015-06-17, Last modification date: 2023-09-27)
Primary citationDurham, T.B.,Toth, J.L.,Klimkowski, V.J.,Cao, J.X.,Siesky, A.M.,Alexander-Chacko, J.,Wu, G.Y.,Dixon, J.T.,McGee, J.E.,Wang, Y.,Guo, S.Y.,Cavitt, R.N.,Schindler, J.,Thibodeaux, S.J.,Calvert, N.A.,Coghlan, M.J.,Sindelar, D.K.,Christe, M.,Kiselyov, V.V.,Michael, M.D.,Sloop, K.W.
Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.
J.Biol.Chem., 290:20044-20059, 2015
Cited by
PubMed: 26085101
DOI: 10.1074/jbc.M115.638205
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.33 Å)
Structure validation

217705

數據於2024-03-27公開中

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