4PDQ

Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neomycin analog

4PDQ の概要

• エントリーDOI: 10.2210/pdb4pdq/pdb
• 分子名称: RNA (5'-*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C-3'), MAGNESIUM ION, (2S)-4-amino-N-{(1R,2S,3R,4R,5S)-5-amino-3-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy }-4-[(2,6-diamino-2,4,6-trideoxy-4-fluoro-alpha-D-galactopyranosyl)oxy]-2-hydroxycyclohexyl}-2-hydroxybutanamide, ... (4 entities in total)
• 機能のキーワード: ribosome, aminoglycoside, rna-antibiotic complex, rna/antibiotic
• 由来する生物種: synthetic
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 15507.20

構造登録者

Hanessian, S.,Saavedra, O.M.,Vilchis-Reyes, M.A.,Maianti, J.P.,Kanazawa, H.,Dozzo, P.,Feeney, L.A.,Armstrong, E.S.,Kondo, J. (登録日: 2014-04-21, 公開日: 2015-01-07, 最終更新日: 2024-03-20)

• 主引用文献: Hanessian, S.,Saavedra, O.M.,Vilchis-Reyes, M.A.,Maianti, J.P.,Kanazawa, H.,Dozzo, P.,Matias, R.D.,Serio, A.,Kondo, J.; Synthesis, broad spectrum antibacterial activity, and X-ray co-crystal structure of the decoding bacterial ribosomal A-site with 4'-deoxy-4'-fluoro neomycin analogs; Chem Sci, 5:4621-4632, 2014; DOI: 10.1039/C4SC01626B

実験手法

X-RAY DIFFRACTION (3 Å)