4PD4

Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action

Summary for 4PD4

DescriptorCytochrome b-c1 complex subunit 1, mitochondrial, Cytochrome b-c1 complex subunit 2, mitochondrial, Cytochrome b, ... (18 entities in total)
Functional Keywordscytochrome bc1 complex, membrane protein complex, antimalarial drug, inhibitor, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
Biological sourceMus musculus (Mouse)
More
Cellular locationMitochondrion inner membrane  P07256 P07257 P00127 P00128 P08525 P22289
Mitochondrion inner membrane ; Multi-pass membrane protein  P00163
Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side P07143
Mitochondrion inner membrane ; Single-pass membrane protein  P08067
Total number of polymer chains11
Total molecular weight251150.07
Authors
Birth, D.,Kao, W.-C.,Hunte, C. (deposition date: 2014-04-17, release date: 2014-06-11, Last modification date: 2017-11-22)
Primary citation
Birth, D.,Kao, W.C.,Hunte, C.
Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action.
Nat Commun, 5:4029-4029, 2014
PubMed: 24893593 (PDB entries with the same primary citation)
DOI: 10.1038/ncomms5029
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.04 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.300223.7%12.4%4.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution