4PD4

Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action

Entity

Chain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
ACytochrome b-c1 complex subunit 1, mitochondrialpolymer43147445.21
UniProt (P07256)
Pfam (PF00675)
Pfam (PF05193)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)Complex III subunit 1,Core protein I,Ubiquinol-cytochrome-c reductase complex core protein 1
BCytochrome b-c1 complex subunit 2, mitochondrialpolymer35238751.91
UniProt (P07257)
Pfam (PF00675)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)Complex III subunit 2,Core protein II,Ubiquinol-cytochrome-c reductase complex core protein 2
CCytochrome bpolymer38543686.61
UniProt (P00163)
Pfam (PF00032)
Pfam (PF00033)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)Complex III subunit 3,Complex III subunit CYTB,Complex III subunit III,Cytochrome b-c1 complex subunit 3,Cytochrome b-c1 complex subunit CYTB,Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
DCytochrome c1, heme protein, mitochondrialpolymer24827807.41
UniProt (P07143)
Pfam (PF02167)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)Complex III subunit 4,Complex III subunit IV,Cytochrome b-c1 complex subunit 4,Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit,Cytochrome c-1
ECytochrome b-c1 complex subunit Rieske, mitochondrialpolymer18520123.01
UniProt (P08067)
Pfam (PF00355)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)Complex III subunit 5,Rieske iron-sulfur protein,RISP,Ubiquinol-cytochrome c reductase iron-sulfur subunit
FCytochrome b-c1 complex subunit 6polymer748854.81
UniProt (P00127)
Pfam (PF02320)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)Complex III subunit 6,Complex III subunit VI,Cytochrome c1 non-heme 17 kDa protein,Mitochondrial hinge protein,Ubiquinol-cytochrome c reductase complex 17 kDa protein
GCytochrome b-c1 complex subunit 7polymer12614452.61
UniProt (P00128)
Pfam (PF02271)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)Complex III subunit 7,Complex III subunit VII,Ubiquinol-cytochrome c reductase c reductase complex 14 kDa protein
HCytochrome b-c1 complex subunit 8polymer9310856.31
UniProt (P08525)
Pfam (PF02939)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)Complex III subunit 8,Complex III subunit VII,Ubiquinol-cytochrome c reductase complex 11 kDa protein,Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C
ICytochrome b-c1 complex subunit 9polymer576535.51
UniProt (P22289)
Pfam (PF05365)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)Complex III subunit 9,Complex III subunit X,Cytochrome c1 non-heme 7.3 kDa protein,Ubiquinol-cytochrome c reductase complex 7.3 kDa protein
JIgh proteinpolymer12714365.81
Pfam (PF07686)
UniProt (by SIFTS) (Q53VQ5)
Mus musculus (Mouse)@PDBj
KIg kappa chain V-V region HP 124E1polymer10711926.41
Pfam (PF07686)
UniProt (by SIFTS) (P01647)
Mus musculus (Mouse)@PDBj
UNDECYL-MALTOSIDEnon-polymer496.61
1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATEnon-polymer705.03
PROTOPORPHYRIN IX CONTAINING FEnon-polymer616.53
2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxynaphthalene-1,4-dionenon-polymer366.81
1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINEnon-polymer748.11
5-(3,7,11,15,19,23-HEXAMETHYL-TETRACOSA-2,6,10,14,18,22-HEXAENYL)-2,3-DIMETHOXY-6-METHYL-BENZENE-1,4-DIOLnon-polymer592.91
FE2/S2 (INORGANIC) CLUSTERnon-polymer175.81

Sequence viewer

Contents of the asymmetric unit

PolymersNumber of chains11
Total molecular weight244805.4
Non-Polymers*Number of molecules11
Total molecular weight6344.7
All*Total molecular weight251150.1
*Water molecules are not included.