4PD4
Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Cytochrome b-c1 complex subunit 1, mitochondrial | polymer | 431 | 47445.2 | 1 | UniProt (P07256) Pfam (PF00675) Pfam (PF05193) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Complex III subunit 1,Core protein I,Ubiquinol-cytochrome-c reductase complex core protein 1 |
2 | B | Cytochrome b-c1 complex subunit 2, mitochondrial | polymer | 352 | 38751.9 | 1 | UniProt (P07257) Pfam (PF00675) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Complex III subunit 2,Core protein II,Ubiquinol-cytochrome-c reductase complex core protein 2 |
3 | C | Cytochrome b | polymer | 385 | 43686.6 | 1 | UniProt (P00163) Pfam (PF00033) Pfam (PF00032) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Complex III subunit 3,Complex III subunit CYTB,Complex III subunit III,Cytochrome b-c1 complex subunit 3,Cytochrome b-c1 complex subunit CYTB,Ubiquinol-cytochrome-c reductase complex cytochrome b subunit |
4 | D | Cytochrome c1, heme protein, mitochondrial | polymer | 248 | 27807.4 | 1 | UniProt (P07143) Pfam (PF02167) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Complex III subunit 4,Complex III subunit IV,Cytochrome b-c1 complex subunit 4,Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit,Cytochrome c-1 |
5 | E | Cytochrome b-c1 complex subunit Rieske, mitochondrial | polymer | 185 | 20123.0 | 1 | UniProt (P08067) Pfam (PF02921) Pfam (PF00355) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Complex III subunit 5,Rieske iron-sulfur protein,RISP,Ubiquinol-cytochrome c reductase iron-sulfur subunit |
6 | F | Cytochrome b-c1 complex subunit 6 | polymer | 74 | 8854.8 | 1 | UniProt (P00127) Pfam (PF02320) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Complex III subunit 6,Complex III subunit VI,Cytochrome c1 non-heme 17 kDa protein,Mitochondrial hinge protein,Ubiquinol-cytochrome c reductase complex 17 kDa protein |
7 | G | Cytochrome b-c1 complex subunit 7 | polymer | 126 | 14452.6 | 1 | UniProt (P00128) Pfam (PF02271) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Complex III subunit 7,Complex III subunit VII,Ubiquinol-cytochrome c reductase c reductase complex 14 kDa protein |
8 | H | Cytochrome b-c1 complex subunit 8 | polymer | 93 | 10856.3 | 1 | UniProt (P08525) Pfam (PF02939) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Complex III subunit 8,Complex III subunit VII,Ubiquinol-cytochrome c reductase complex 11 kDa protein,Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C |
9 | I | Cytochrome b-c1 complex subunit 9 | polymer | 57 | 6535.5 | 1 | UniProt (P22289) Pfam (PF05365) In PDB | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Complex III subunit 9,Complex III subunit X,Cytochrome c1 non-heme 7.3 kDa protein,Ubiquinol-cytochrome c reductase complex 7.3 kDa protein |
10 | J | Igh protein | polymer | 127 | 14365.8 | 1 | Pfam (PF07686) UniProt (by SIFTS) (Q53VQ5) In PDB | Mus musculus (Mouse) | |
11 | K | Ig kappa chain V-V region HP 124E1 | polymer | 107 | 11926.4 | 1 | Pfam (PF07686) UniProt (by SIFTS) (P01647) In PDB | Mus musculus (Mouse) | |
12 | A | UNDECYL-MALTOSIDE | non-polymer | 496.6 | 1 | Chemie (UMQ) | |||
13 | A, C, E | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE | non-polymer | 705.0 | 3 | Chemie (3PH) | |||
14 | C, D | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 3 | Chemie (HEM) | |||
15 | C | 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxynaphthalene-1,4-dione | non-polymer | 366.8 | 1 | Chemie (AOQ) | |||
16 | C | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 1 | Chemie (3PE) | |||
17 | C | 5-(3,7,11,15,19,23-HEXAMETHYL-TETRACOSA-2,6,10,14,18,22-HEXAENYL)-2,3-DIMETHOXY-6-METHYL-BENZENE-1,4-DIOL | non-polymer | 592.9 | 1 | Chemie (UQ6) | |||
18 | E | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 1 | Chemie (FES) |
Sequence modifications
A: 27 - 457 (UniProt: P07256)
PDB | External Database | Details |
---|---|---|
Asp 153 | Glu 153 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 11 |
Total formula weight | 244805.4 | |
Non-Polymers* | Number of molecules | 11 |
Total formula weight | 6344.7 | |
All* | Total formula weight | 251150.1 |