4PD4
Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cytochrome b-c1 complex subunit 1, mitochondrial | polymer | 431 | 47445.2 | 1 | UniProt (P07256) Pfam (PF00675) Pfam (PF05193) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Complex III subunit 1,Core protein I,Ubiquinol-cytochrome-c reductase complex core protein 1 |
| 2 | B (B) | Cytochrome b-c1 complex subunit 2, mitochondrial | polymer | 352 | 38751.9 | 1 | UniProt (P07257) Pfam (PF00675) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Complex III subunit 2,Core protein II,Ubiquinol-cytochrome-c reductase complex core protein 2 |
| 3 | C (C) | Cytochrome b | polymer | 385 | 43686.6 | 1 | UniProt (P00163) Pfam (PF00033) Pfam (PF00032) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Complex III subunit 3,Complex III subunit CYTB,Complex III subunit III,Cytochrome b-c1 complex subunit 3,Cytochrome b-c1 complex subunit CYTB,Ubiquinol-cytochrome-c reductase complex cytochrome b subunit |
| 4 | D (D) | Cytochrome c1, heme protein, mitochondrial | polymer | 248 | 27807.4 | 1 | UniProt (P07143) Pfam (PF02167) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Complex III subunit 4,Complex III subunit IV,Cytochrome b-c1 complex subunit 4,Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit,Cytochrome c-1 |
| 5 | E (E) | Cytochrome b-c1 complex subunit Rieske, mitochondrial | polymer | 185 | 20123.0 | 1 | UniProt (P08067) Pfam (PF02921) Pfam (PF00355) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Complex III subunit 5,Rieske iron-sulfur protein,RISP,Ubiquinol-cytochrome c reductase iron-sulfur subunit |
| 6 | F (F) | Cytochrome b-c1 complex subunit 6 | polymer | 74 | 8854.8 | 1 | UniProt (P00127) Pfam (PF02320) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Complex III subunit 6,Complex III subunit VI,Cytochrome c1 non-heme 17 kDa protein,Mitochondrial hinge protein,Ubiquinol-cytochrome c reductase complex 17 kDa protein |
| 7 | G (G) | Cytochrome b-c1 complex subunit 7 | polymer | 126 | 14452.6 | 1 | UniProt (P00128) Pfam (PF02271) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Complex III subunit 7,Complex III subunit VII,Ubiquinol-cytochrome c reductase c reductase complex 14 kDa protein |
| 8 | H (H) | Cytochrome b-c1 complex subunit 8 | polymer | 93 | 10856.3 | 1 | UniProt (P08525) Pfam (PF02939) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Complex III subunit 8,Complex III subunit VII,Ubiquinol-cytochrome c reductase complex 11 kDa protein,Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C |
| 9 | I (I) | Cytochrome b-c1 complex subunit 9 | polymer | 57 | 6535.5 | 1 | UniProt (P22289) Pfam (PF05365) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Complex III subunit 9,Complex III subunit X,Cytochrome c1 non-heme 7.3 kDa protein,Ubiquinol-cytochrome c reductase complex 7.3 kDa protein |
| 10 | J (J) | Igh protein | polymer | 127 | 14365.8 | 1 | UniProt (by SIFTS) (Q53VQ5) | Mus musculus (Mouse) | |
| 11 | K (K) | Ig kappa chain V-V region HP 124E1 | polymer | 107 | 11926.4 | 1 | Pfam (PF07686) UniProt (by SIFTS) (P01647) | Mus musculus (Mouse) | |
| 12 | L (A) | UNDECYL-MALTOSIDE | non-polymer | 496.6 | 1 | Chemie (UMQ) PubChem (44462510) PubChem (58112566) PubChem (59518662) PubChem (46936455) PubChem (68343856) PubChem (70699429) PubChem (70701336) PubChem (70701337) PubChem (70839940) PubChem (70841479) PubChem (70863062) PubChem (71300308) PubChem (447793) PubChem (89952000) PubChem (5076192) PubChem (70699426) PubChem (70699431) PubChem (70796434) PubChem (71300307) PubChem (92132109) PubChem (124643296) PubChem (126731015) PubChem (126731038) PubChem (126735855) PubChem (126735857) PubChem (131632466) PubChem (169544249) | |||
| 13 | M, S, V (A, C, E) | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE | non-polymer | 705.0 | 3 | Chemie (3PH) PubChem (447938) PubChem (86641) PubChem (16211043) | |||
| 14 | N, O, T (C, D) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 3 | Chemie (HEM) | |||
| 15 | P (C) | 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxynaphthalene-1,4-dione | non-polymer | 366.8 | 1 | Chemie (AOQ) | |||
| 16 | Q (C) | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 1 | Chemie (3PE) | |||
| 17 | R (C) | 5-(3,7,11,15,19,23-HEXAMETHYL-TETRACOSA-2,6,10,14,18,22-HEXAENYL)-2,3-DIMETHOXY-6-METHYL-BENZENE-1,4-DIOL | non-polymer | 592.9 | 1 | Chemie (UQ6) PubChem (3393375) PubChem (5289539) PubChem (5813154) PubChem (135397738) PubChem (172636440) PubChem (170838524) PubChem (172636439) PubChem (175646711) | |||
| 18 | U (E) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 1 | Chemie (FES) |
Sequence modifications
A: 27 - 457 (UniProt: P07256)
| PDB | External Database | Details |
|---|---|---|
| Asp 153 | Glu 153 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 11 |
| Total formula weight | 244805.4 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 6344.7 | |
| All* | Total formula weight | 251150.1 |
