4PCJ
Modifications to toxic CUG RNAs induce structural stability and rescue mis-splicing in Myotonic Dystrophy
Summary for 4PCJ
Entry DOI | 10.2210/pdb4pcj/pdb |
Related | 4FNJ |
Descriptor | trCUG-3('5), MAGNESIUM ION (3 entities in total) |
Functional Keywords | pseudou, cug repeats, tetraloop receptor, rna |
Biological source | synthetic construct |
Total number of polymer chains | 1 |
Total formula weight | 11375.22 |
Authors | Coonrod, L.A.,Reister, E.E.,Berglund, J.A. (deposition date: 2014-04-15, release date: 2014-10-29, Last modification date: 2023-09-27) |
Primary citation | deLorimier, E.,Coonrod, L.A.,Copperman, J.,Taber, A.,Reister, E.E.,Sharma, K.,Todd, P.K.,Guenza, M.G.,Berglund, J.A. Modifications to toxic CUG RNAs induce structural stability, rescue mis-splicing in a myotonic dystrophy cell model and reduce toxicity in a myotonic dystrophy zebrafish model. Nucleic Acids Res., 42:12768-12778, 2014 Cited by PubMed: 25303993DOI: 10.1093/nar/gku941 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report