4PCJ

Modifications to toxic CUG RNAs induce structural stability and rescue mis-splicing in Myotonic Dystrophy

Summary for 4PCJ

• Entry DOI: 10.2210/pdb4pcj/pdb
• Related: 4FNJ
• Descriptor: trCUG-3('5), MAGNESIUM ION (3 entities in total)
• Functional Keywords: pseudou, cug repeats, tetraloop receptor, rna
• Biological source: synthetic construct
• Total number of polymer chains: 1
• Total formula weight: 11375.22

Authors

Coonrod, L.A.,Reister, E.E.,Berglund, J.A. (deposition date: 2014-04-15, release date: 2014-10-29, Last modification date: 2023-09-27)

• Primary citation: deLorimier, E.,Coonrod, L.A.,Copperman, J.,Taber, A.,Reister, E.E.,Sharma, K.,Todd, P.K.,Guenza, M.G.,Berglund, J.A.; Modifications to toxic CUG RNAs induce structural stability, rescue mis-splicing in a myotonic dystrophy cell model and reduce toxicity in a myotonic dystrophy zebrafish model.; Nucleic Acids Res., 42:12768-12778, 2014; PubMed: 25303993; DOI: 10.1093/nar/gku941

Experimental method

X-RAY DIFFRACTION (1.9 Å)