4P7M

Crystal structure of Plasmodium falciparum MIF in complex with 3-[(2-methyl-6-phenylpyridin-4-yl)oxy]phenol

4P7M の概要

• エントリーDOI: 10.2210/pdb4p7m/pdb
• 関連するPDBエントリー: 4P7S
• 分子名称: Macrophage migration inhibitory factor-like protein, 3-[(2-methyl-6-phenylpyridin-4-yl)oxy]phenol (2 entities in total)
• 機能のキーワード: malaria, inhibitor, active site, complex, cytokine-inhibitor complex, cytokine/inhibitor
• 由来する生物種: Plasmodium falciparum
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 38275.98

構造登録者

Pantouris, G.,Lolis, E. (登録日: 2014-03-27, 公開日: 2014-10-15, 最終更新日: 2023-12-27)

主引用文献

Pantouris, G.,Rajasekaran, D.,Garcia, A.B.,Ruiz, V.G.,Leng, L.,Jorgensen, W.L.,Bucala, R.,Lolis, E.J.
Crystallographic and Receptor Binding Characterization of Plasmodium falciparum Macrophage Migration Inhibitory Factor Complexed to Two Potent Inhibitors.
J.Med.Chem., 57:8652-8656, 2014

PubMed Abstract: We report the crystal structures of two inhibitors of Plasmodium falciparum macrophage migration inhibitory factor (PfMIF) with nanomolar Ki's, analyze their interactions with the active site of PfMIF, and provide explanations regarding their selectivity of PfMIF versus human MIF. These inhibitors were also found to selectively inhibit interactions between PfMIF and the human MIF receptor CD74. The results of this study provide the framework for the development of new therapeutics that target PfMIF.

PubMed: 25268646
DOI: 10.1021/jm501168q

実験手法

X-RAY DIFFRACTION (3.02 Å)