4P7A

Crystal Structure of human MLH1

「3NA3」から置き換えられました

4P7A の概要

• エントリーDOI: 10.2210/pdb4p7a/pdb
• 分子名称: DNA mismatch repair protein Mlh1, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: structural genomics consortium, dna mismatch repair, dna damage, sgc, dna binding protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39106.51

構造登録者

Tempel, W.,Lam, R.,Zeng, H.,Walker, J.R.,Loppnau, P.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Min, J.,Wu, H.,Structural Genomics Consortium (SGC) (登録日: 2014-03-26, 公開日: 2014-04-09, 最終更新日: 2023-12-27)

主引用文献

Wu, H.,Zeng, H.,Lam, R.,Tempel, W.,Kerr, I.D.,Min, J.
Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome.
Acta Crystallogr.,Sect.F, 71:981-985, 2015

PubMed Abstract: Mismatch repair prevents the accumulation of erroneous insertions/deletions and non-Watson-Crick base pairs in the genome. Pathogenic mutations in the MLH1 gene are associated with a predisposition to Lynch and Turcot's syndromes. Although genetic testing for these mutations is available, robust classification of variants requires strong clinical and functional support. Here, the first structure of the N-terminus of human MLH1, determined by X-ray crystallography, is described. The structure shares a high degree of similarity with previously determined prokaryotic MLH1 homologs; however, this structure affords a more accurate platform for the classification of MLH1 variants.

PubMed: 26249686
DOI: 10.1107/S2053230X15010183

実験手法

X-RAY DIFFRACTION (2.3 Å)