4P6G
Crystal Structure of Human Cathepsin S Bound to a Non-covalent Inhibitor.
Summary for 4P6G
Entry DOI | 10.2210/pdb4p6g/pdb |
Related | 4P6E |
Descriptor | Cathepsin S, (3R,4S)-4-[(4-fluorobenzoyl)amino]-6-[4-(oxetan-3-yl)piperazin-1-yl]-3,4-dihydro-2H-chromen-3-yl methylcarbamate (3 entities in total) |
Functional Keywords | cathespsin s, non-covalent inhibitor, cysteine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Lysosome: P25774 |
Total number of polymer chains | 4 |
Total formula weight | 102478.64 |
Authors | Wang, Y.,Jadhav, P.K. (deposition date: 2014-03-24, release date: 2014-10-29, Last modification date: 2023-12-27) |
Primary citation | Jadhav, P.K.,Schiffler, M.A.,Gavardinas, K.,Kim, E.J.,Matthews, D.P.,Staszak, M.A.,Coffey, D.S.,Shaw, B.W.,Cassidy, K.C.,Brier, R.A.,Zhang, Y.,Christie, R.M.,Matter, W.F.,Qing, K.,Durbin, J.D.,Wang, Y.,Deng, G.G. Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm. Acs Med.Chem.Lett., 5:1138-1142, 2014 Cited by PubMed: 25313327DOI: 10.1021/ml500283g PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.58 Å) |
Structure validation
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