4P68
Electrostatics of Active Site Microenvironments for E. coli DHFR
Summary for 4P68
Entry DOI | 10.2210/pdb4p68/pdb |
Related | 4P66 |
Descriptor | Dihydrofolate reductase, METHOTREXATE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total) |
Functional Keywords | electrostatics, catalysis, oxidoreductase, dhfr |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 19382.29 |
Authors | Liu, C.T.,Layfield, J.P.,Stewart III, R.J.,French, J.B.,Hanoian, P.,Asbury, J.B.,Hammes-Schiffer, S.,Benkovic, S.J. (deposition date: 2014-03-22, release date: 2014-07-16, Last modification date: 2023-12-27) |
Primary citation | Liu, C.T.,Layfield, J.P.,Stewart, R.J.,French, J.B.,Hanoian, P.,Asbury, J.B.,Hammes-Schiffer, S.,Benkovic, S.J. Probing the electrostatics of active site microenvironments along the catalytic cycle for Escherichia coli dihydrofolate reductase. J.Am.Chem.Soc., 136:10349-10360, 2014 Cited by PubMed: 24977791DOI: 10.1021/ja5038947 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.26 Å) |
Structure validation
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