Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0044281 | biological_process | small molecule metabolic process |
| A | 0046452 | biological_process | dihydrofolate metabolic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046655 | biological_process | folic acid metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050661 | molecular_function | NADP binding |
| A | 0070401 | molecular_function | NADP+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue MTX A 201 |
| Chain | Residue |
| A | ILE5 |
| A | ILE94 |
| A | TYR100 |
| A | NAP202 |
| A | HOH328 |
| A | ALA6 |
| A | ALA7 |
| A | MET20 |
| A | ASP27 |
| A | PHE31 |
| A | ILE50 |
| A | XCN54 |
| A | ARG57 |
| site_id | AC2 |
| Number of Residues | 28 |
| Details | binding site for residue NAP A 202 |
| Chain | Residue |
| A | ALA6 |
| A | ALA7 |
| A | ILE14 |
| A | ASN18 |
| A | ALA19 |
| A | MET20 |
| A | GLY43 |
| A | ARG44 |
| A | HIS45 |
| A | THR46 |
| A | LEU62 |
| A | SER63 |
| A | SER64 |
| A | GLN65 |
| A | LYS76 |
| A | ILE94 |
| A | GLY96 |
| A | GLY97 |
| A | ARG98 |
| A | VAL99 |
| A | TYR100 |
| A | GLN102 |
| A | ASP131 |
| A | GLU139 |
| A | MTX201 |
| A | HOH303 |
| A | HOH315 |
| A | HOH333 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue ACT A 203 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue ACT A 204 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 205 |
| Chain | Residue |
| A | ASP116 |
| A | HIS149 |
| A | ARG159 |
| A | HOH306 |
| A | HOH324 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 23 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGmenaMPWnlpa.DlawFkrnT |
| Chain | Residue | Details |
| A | VAL13-THR35 | |
