4P4X

Dodecamer formed by a macrocyclic peptide derived from beta-2-microglobulin (63-69) - (ORN)YLL(PHI)YTE(ORN)KVA(MLE)AVK

Summary for 4P4X

• Entry DOI: 10.2210/pdb4p4x/pdb
• Related: 4P4V 4P4W 4P4Y 4P4Z
• Descriptor: CYCLIC HEXADECAPEPTIDE (ORN)YLL(PH7)YTE(ORN)KVA(MLE)AVK, SULFATE ION, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: amyloid, beta-2-microglobulin, macrocycle, dodecamer, de novo protein
• Biological source: synthetic construct
• Total number of polymer chains: 12
• Total formula weight: 25178.04

Authors

Spencer, R.K.,Nowick, J.S. (deposition date: 2014-03-13, release date: 2015-05-06, Last modification date: 2023-12-27)

• Primary citation: Spencer, R.K.,Kreutzer, A.G.,Salveson, P.J.,Li, H.,Nowick, J.S.; X-ray Crystallographic Structures of Oligomers of Peptides Derived from beta 2-Microglobulin.; J.Am.Chem.Soc., 137:6304-6311, 2015; PubMed: 25915729; DOI: 10.1021/jacs.5b01673

Experimental method

X-RAY DIFFRACTION (1.898 Å)