4P3H

Crystal structure of Kaposi's sarcoma-associated herpesvirus (KSHV) protease in complex with dimer disruptor

Summary for 4P3H

• Entry DOI: 10.2210/pdb4p3h/pdb
• Related: 4P2T
• Descriptor: KSHV protease, N-[2-benzyl-4-(1H-tetrazol-5-yl)phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide, GLYCEROL, ... (5 entities in total)
• Functional Keywords: protein-protein interaction inhibition, serine protease, inhibitor complex, beta barrel and alpha helices, hydrolase
• Biological source: Human herpesvirus 8 (HHV-8)
• Total number of polymer chains: 2
• Total formula weight: 43992.24

Authors

Gable, J.E. (deposition date: 2014-03-07, release date: 2014-07-23, Last modification date: 2023-09-27)

• Primary citation: Gable, J.E.,Lee, G.M.,Jaishankar, P.,Hearn, B.R.,Waddling, C.A.,Renslo, A.R.,Craik, C.S.; Broad-spectrum allosteric inhibition of herpesvirus proteases.; Biochemistry, 53:4648-4660, 2014; PubMed: 24977643; DOI: 10.1021/bi5003234

Experimental method

X-RAY DIFFRACTION (1.45 Å)