4P3H
Crystal structure of Kaposi's sarcoma-associated herpesvirus (KSHV) protease in complex with dimer disruptor
Summary for 4P3H
Entry DOI | 10.2210/pdb4p3h/pdb |
Related | 4P2T |
Descriptor | KSHV protease, N-[2-benzyl-4-(1H-tetrazol-5-yl)phenyl]-6-(cyclohexylmethyl)pyridine-2-carboxamide, GLYCEROL, ... (5 entities in total) |
Functional Keywords | protein-protein interaction inhibition, serine protease, inhibitor complex, beta barrel and alpha helices, hydrolase |
Biological source | Human herpesvirus 8 (HHV-8) |
Total number of polymer chains | 2 |
Total formula weight | 43992.24 |
Authors | Gable, J.E. (deposition date: 2014-03-07, release date: 2014-07-23, Last modification date: 2023-09-27) |
Primary citation | Gable, J.E.,Lee, G.M.,Jaishankar, P.,Hearn, B.R.,Waddling, C.A.,Renslo, A.R.,Craik, C.S. Broad-spectrum allosteric inhibition of herpesvirus proteases. Biochemistry, 53:4648-4660, 2014 Cited by PubMed: 24977643DOI: 10.1021/bi5003234 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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