4P38

Human 11beta-Hydroxysteroid Dehydrogenase Type 1 in complex with AZD8329

4P38 の概要

• エントリーDOI: 10.2210/pdb4p38/pdb
• 関連するPDBエントリー: 4HFR
• 分子名称: Corticosteroid 11-beta-dehydrogenase isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid, ... (5 entities in total)
• 機能のキーワード: alpha beta, rossmann fold, nadp, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Endoplasmic reticulum membrane ; Single-pass type II membrane protein : P28845
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 60838.64

構造登録者

Ogg, D.,Hargreaves, D.,Gerhardt, S. (登録日: 2014-03-06, 公開日: 2014-04-30, 最終更新日: 2024-02-28)

• 主引用文献: Scott, J.S.,deSchoolmeester, J.,Kilgour, E.,Mayers, R.M.,Packer, M.J.,Hargreaves, D.,Gerhardt, S.,Ogg, D.J.,Rees, A.,Selmi, N.,Stocker, A.,Swales, J.G.,Whittamore, P.R.; Novel acidic 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329).; J.Med.Chem., 55:10136-10147, 2012; PubMed: 23088558; DOI: 10.1021/jm301252n

実験手法

X-RAY DIFFRACTION (2.8 Å)