4P2T

Crystal structure of Kaposi's sarcoma-associated herpesvirus (KSHV) protease in complex with a dimer disruptor

4P2T の概要

• エントリーDOI: 10.2210/pdb4p2t/pdb
• 分子名称: KSHV Protease, 6-(cyclohexylmethyl)-N-[4-(methylsulfonylcarbamoyl)-2-(phenylmethyl)phenyl]pyridine-2-carboxamide, DIMETHYL SULFOXIDE, ... (4 entities in total)
• 機能のキーワード: protein-protein interaction inhibition, serine protease, inhibitor complex, beta barrel and alpha helices, hydrolase
• 由来する生物種: Human herpesvirus 8 (HHV-8)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 44237.50

構造登録者

Gable, J.E. (登録日: 2014-03-04, 公開日: 2014-07-16, 最終更新日: 2023-09-27)

• 主引用文献: Gable, J.E.,Lee, G.M.,Jaishankar, P.,Hearn, B.R.,Waddling, C.A.,Renslo, A.R.,Craik, C.S.; Broad-spectrum allosteric inhibition of herpesvirus proteases.; Biochemistry, 53:4648-4660, 2014; PubMed: 24977643; DOI: 10.1021/bi5003234

実験手法

X-RAY DIFFRACTION (2.15 Å)