4P0W

Human farnesyl diphosphate synthase in complex with Arenarone and zoledronate

4P0W の概要

• エントリーDOI: 10.2210/pdb4p0w/pdb
• 分子名称: Farnesyl pyrophosphate synthase, 2-{[(1S,2R,4aS,8aR)-1,2,4a-trimethyl-5-methylidenedecahydronaphthalen-1-yl]methyl}cyclohexa-2,5-diene-1,4-dione, ZOLEDRONIC ACID, ... (5 entities in total)
• 機能のキーワード: fpps, inhibitor, complex, prenyl synthase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40687.14

構造登録者

Liu, Y.L.,Oldfield, E. (登録日: 2014-02-23, 公開日: 2014-07-02, 最終更新日: 2023-12-27)

• 主引用文献: Liu, Y.L.,Lindert, S.,Zhu, W.,Wang, K.,McCammon, J.A.,Oldfield, E.; Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site.; Proc.Natl.Acad.Sci.USA, 111:E2530-E2539, 2014; PubMed: 24927548; DOI: 10.1073/pnas.1409061111

実験手法

X-RAY DIFFRACTION (2.406 Å)