4P0N
Crystal structure of PDE10a with a novel Imidazo[4,5-b]pyridine inhibitor
Summary for 4P0N
Entry DOI | 10.2210/pdb4p0n/pdb |
Descriptor | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, N-[trans-3-(2-methoxy-3H-imidazo[4,5-b]pyridin-3-yl)cyclobutyl]-1,3-benzothiazol-2-amine, N-[cis-3-(2-methoxy-3H-imidazo[4,5-b]pyridin-3-yl)cyclobutyl]-1,3-benzothiazol-2-amine, ... (7 entities in total) |
Functional Keywords | hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q9Y233 |
Total number of polymer chains | 2 |
Total formula weight | 80207.07 |
Authors | Chmait, S. (deposition date: 2014-02-21, release date: 2014-10-01, Last modification date: 2023-12-27) |
Primary citation | Hu, E.,Andrews, K.,Chmait, S.,Zhao, X.,Davis, C.,Miller, S.,Hill Della Puppa, G.,Dovlatyan, M.,Chen, H.,Lester-Zeiner, D.,Able, J.,Biorn, C.,Ma, J.,Shi, J.,Treanor, J.,Allen, J.R. Discovery of Novel Imidazo[4,5-b]pyridines as Potent and Selective Inhibitors of Phosphodiesterase 10A (PDE10A). Acs Med.Chem.Lett., 5:700-705, 2014 Cited by PubMed: 24944747DOI: 10.1021/ml5000993 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.08 Å) |
Structure validation
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