4P0N

Crystal structure of PDE10a with a novel Imidazo[4,5-b]pyridine inhibitor

Summary for 4P0N

• Entry DOI: 10.2210/pdb4p0n/pdb
• Descriptor: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, N-[trans-3-(2-methoxy-3H-imidazo[4,5-b]pyridin-3-yl)cyclobutyl]-1,3-benzothiazol-2-amine, N-[cis-3-(2-methoxy-3H-imidazo[4,5-b]pyridin-3-yl)cyclobutyl]-1,3-benzothiazol-2-amine, ... (7 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: Q9Y233
• Total number of polymer chains: 2
• Total formula weight: 80207.07

Authors

Chmait, S. (deposition date: 2014-02-21, release date: 2014-10-01, Last modification date: 2023-12-27)

• Primary citation: Hu, E.,Andrews, K.,Chmait, S.,Zhao, X.,Davis, C.,Miller, S.,Hill Della Puppa, G.,Dovlatyan, M.,Chen, H.,Lester-Zeiner, D.,Able, J.,Biorn, C.,Ma, J.,Shi, J.,Treanor, J.,Allen, J.R.; Discovery of Novel Imidazo[4,5-b]pyridines as Potent and Selective Inhibitors of Phosphodiesterase 10A (PDE10A).; Acs Med.Chem.Lett., 5:700-705, 2014; PubMed: 24944747; DOI: 10.1021/ml5000993

Experimental method

X-RAY DIFFRACTION (2.08 Å)