4OX2

I45T cytosolic phosphoenolpyruvate carboxykinase in complex with beta-sulfopyruvate and GTP

Summary for 4OX2

Entry DOI	10.2210/pdb4ox2/pdb
Descriptor	Phosphoenolpyruvate carboxykinase, cytosolic [GTP], MANGANESE (II) ION, GUANOSINE-5'-TRIPHOSPHATE, ... (8 entities in total)
Functional Keywords	kinase, gluconeogenesis, lyase
Biological source	Rattus norvegicus (Rat)
Total number of polymer chains	2
Total formula weight	141300.11
Authors	Holyoak, T. (deposition date: 2014-02-04, release date: 2014-06-11, Last modification date: 2023-09-27)
Primary citation	Adams, D.R.,Yuan, H.,Holyoak, T.,Arajs, K.H.,Hakimi, P.,Markello, T.C.,Wolfe, L.A.,Vilboux, T.,Burton, B.K.,Fajardo, K.F.,Grahame, G.,Holloman, C.,Sincan, M.,Smith, A.C.,Wells, G.A.,Huang, Y.,Vega, H.,Snyder, J.P.,Golas, G.A.,Tifft, C.J.,Boerkoel, C.F.,Hanson, R.W.,Traynelis, S.F.,Kerr, D.S.,Gahl, W.A. Three rare diseases in one Sib pair: RAI1, PCK1, GRIN2B mutations associated with Smith-Magenis Syndrome, cytosolic PEPCK deficiency and NMDA receptor glutamate insensitivity. Mol.Genet.Metab., 113:161-170, 2014 Cited by PubMed: 24863970 DOI: 10.1016/j.ymgme.2014.04.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation