4OW8

Crystal structure of kinase domain of PknA from Mtb

4OW8 の概要

• エントリーDOI: 10.2210/pdb4ow8/pdb
• 分子名称: Serine/threonine-protein kinase PknA, GLYCEROL, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: pkna, kinase, drug target, mtb, transferase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30637.18

構造登録者

Ravala, S.K.,Singh, S.,Yadav, G.S.,Karthikeyan, S.,Chakraborti, P.K. (登録日: 2014-01-31, 公開日: 2015-02-04, 最終更新日: 2023-09-27)

• 主引用文献: Ravala, S.K.,Singh, S.,Yadav, G.S.,Kumar, S.,Karthikeyan, S.,Chakraborti, P.K.; Evidence that phosphorylation of threonine in the GT motif triggers activation of PknA, a eukaryotic-type serine/threonine kinase from Mycobacterium tuberculosis.; Febs J., 282:1419-1431, 2015; PubMed: 25665034; DOI: 10.1111/febs.13230

実験手法

X-RAY DIFFRACTION (2.03 Å)