4OW1

Crystal Structure of Resuscitation Promoting Factor C

4OW1 の概要

• エントリーDOI: 10.2210/pdb4ow1/pdb
• 分子名称: Resuscitation-promoting factor RpfC, 1,2-ETHANEDIOL (3 entities in total)
• 機能のキーワード: resuscitation promoting factor, peptidoglycan, transglycosylase, hydrolase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 74630.50

構造登録者

Chauviac, F.X.,Quay, D.H.X.,Cohen-Gonsaud, M.,Keep, N.H. (登録日: 2014-01-29, 公開日: 2014-06-18, 最終更新日: 2024-10-09)

主引用文献

Chauviac, F.X.,Robertson, G.,Quay, D.H.,Bagneris, C.,Dumas, C.,Henderson, B.,Ward, J.,Keep, N.H.,Cohen-Gonsaud, M.
The RpfC (Rv1884) atomic structure shows high structural conservation within the resuscitation-promoting factor catalytic domain.
Acta Crystallogr.,Sect.F, 70:1022-1026, 2014

PubMed Abstract: The first structure of the catalytic domain of RpfC (Rv1884), one of the resuscitation-promoting factors (RPFs) from Mycobacterium tuberculosis, is reported. The structure was solved using molecular replacement once the space group had been correctly identified as twinned P21 rather than the apparent C2221 by searching for anomalous scattering sites in P1. The structure displays a very high degree of structural conservation with the previously published structures of the catalytic domains of RpfB (Rv1009) and RpfE (Rv2450). This structural conservation highlights the importance of the versatile domain composition of the RPF family.

PubMed: 25084374
DOI: 10.1107/S2053230X1401317X

実験手法

X-RAY DIFFRACTION (1.9 Å)