4ORZ

HIV-1 Nef protein in complex with single domain antibody sdAb19 and an engineered Hck SH3 domain

4ORZ の概要

• エントリーDOI: 10.2210/pdb4orz/pdb
• 関連するPDBエントリー: 3RBB 3REA
• 分子名称: Tyrosine-protein kinase HCK, Protein Nef, single domain antibody sdAb19, ... (4 entities in total)
• 機能のキーワード: sh3 domain, immunglobolin fold, antibodies, epitopes, hiv antibodies, hiv accessory proteins, pxxp motif, complementarity determining regions, transferase-apoptosis-immune system complex, transferase/apoptosis/immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Isoform 1: Lysosome. Isoform 2: Cell membrane; Lipid-anchor. Cytoplasmic vesicle, secretory vesicle: P08631; Host cell membrane; Lipid-anchor; Cytoplasmic side (By similarity): P03407
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 37439.97

構造登録者

Geyer, M.,Lulf, S. (登録日: 2014-02-12, 公開日: 2014-03-26, 最終更新日: 2023-09-20)

主引用文献

Lulf, S.,Matz, J.,Rouyez, M.C.,Jarviluoma, A.,Saksela, K.,Benichou, S.,Geyer, M.
Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody.
Retrovirology, 11:24-24, 2014

PubMed Abstract: The HIV-1 Nef protein is essential for AIDS pathogenesis by its interaction with host cell surface receptors and signaling factors. Despite its critical role as a virulence factor Nef is not targeted by current antiviral strategies.

PubMed: 24620746
DOI: 10.1186/1742-4690-11-24

実験手法

X-RAY DIFFRACTION (2 Å)