4ORX

Three-dimensional structure of the C65A-K59A double mutant of Human lipocalin-type Prostaglandin D Synthase holo-form

Summary for 4ORX

• Entry DOI: 10.2210/pdb4orx/pdb
• Related: 4ORR 4ORS 4ORU 4ORW 4ORY 4OS0 4OS3 4OS8
• Descriptor: Prostaglandin-H2 D-isomerase, SULFATE ION, 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL, ... (4 entities in total)
• Functional Keywords: lipocalin-type prostaglandin-d synthase, peg, isomerase
• Biological source: Homo sapiens (human)
• Cellular location: Rough endoplasmic reticulum : P41222
• Total number of polymer chains: 2
• Total formula weight: 43236.75

Authors

Perduca, M.,Bovi, M.,Bertinelli, M.,Bertini, E.,Destefanis, L.,Carrizo, M.E.,Capaldi, S.,Monaco, H.L. (deposition date: 2014-02-12, release date: 2014-08-06, Last modification date: 2014-12-17)

• Primary citation: Perduca, M.,Bovi, M.,Bertinelli, M.,Bertini, E.,Destefanis, L.,Carrizo, M.E.,Capaldi, S.,Monaco, H.L.; High-resolution structures of mutants of residues that affect access to the ligand-binding cavity of human lipocalin-type prostaglandin D synthase.; Acta Crystallogr.,Sect.D, 70:2125-2138, 2014; PubMed: 25084332; DOI: 10.1107/S1399004714012462

Experimental method

X-RAY DIFFRACTION (1.6 Å)