4OR8

Crystal structure of Marburg virus VP24

4OR8 の概要

• エントリーDOI: 10.2210/pdb4or8/pdb
• 分子名称: Membrane-associated protein VP24 (2 entities in total)
• 機能のキーワード: marburg, vp24, pyramidal fold, protein, ebola, virus, viral, viral protein
• 由来する生物種: Marburg virus - Musoke, Kenya, 1980 (MARV)
• 細胞内の位置: Virion membrane; Peripheral membrane protein: P35256
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 60774.45

構造登録者

Zhang, A.P.P.,Bornholdt, Z.,Abelson, D.,Saphire, E.O. (登録日: 2014-02-11, 公開日: 2014-03-26, 最終更新日: 2024-02-28)

主引用文献

Zhang, A.P.,Bornholdt, Z.A.,Abelson, D.M.,Saphire, E.O.
Crystal Structure of Marburg Virus VP24.
J.Virol., 88:5859-5863, 2014

PubMed Abstract: The VP24 protein plays an essential, albeit poorly understood role in the filovirus life cycle. VP24 is only 30% identical between Marburg virus and the ebolaviruses. Furthermore, VP24 from the ebolaviruses is immunosuppressive, while that of Marburg virus is not. The crystal structure of Marburg virus VP24, presented here, reveals that although the core is similar between the viral genera, Marburg VP24 is distinguished by a projecting β-shelf and an alternate conformation of the N-terminal polypeptide.

PubMed: 24574400
DOI: 10.1128/JVI.03565-13

実験手法

X-RAY DIFFRACTION (2.654 Å)