4OR7

Klebsiella pneumoniae dihydrofolate reductase complexed with NADPH and 6-ethyl-5-{3-[3-(pyrimidin-5-yl)phenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine

4OR7 の概要

• エントリーDOI: 10.2210/pdb4or7/pdb
• 関連するPDBエントリー: 4OSG
• 分子名称: Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-ethyl-5-{3-[3-(pyrimidin-5-yl)phenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine, ... (4 entities in total)
• 機能のキーワード: 5, 6, 7, 8-tetrahydrofolate; 7, 8-dihydrofolate, hydride shift, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Klebsiella pneumoniae CG43
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19886.94

構造登録者

Lamb, K.M.,Anderson, A.C. (登録日: 2014-02-11, 公開日: 2014-12-03, 最終更新日: 2024-02-28)

• 主引用文献: Lamb, K.M.,Lombardo, M.N.,Alverson, J.,Priestley, N.D.,Wright, D.L.,Anderson, A.C.; Crystal Structures of Klebsiella pneumoniae Dihydrofolate Reductase Bound to Propargyl-Linked Antifolates Reveal Features for Potency and Selectivity.; Antimicrob.Agents Chemother., 58:7484-7491, 2014; PubMed: 25288083; DOI: 10.1128/AAC.03555-14

実験手法

X-RAY DIFFRACTION (1.76 Å)