4OR7
Klebsiella pneumoniae dihydrofolate reductase complexed with NADPH and 6-ethyl-5-{3-[3-(pyrimidin-5-yl)phenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine
4OR7 の概要
エントリーDOI | 10.2210/pdb4or7/pdb |
関連するPDBエントリー | 4OSG |
分子名称 | Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-ethyl-5-{3-[3-(pyrimidin-5-yl)phenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine, ... (4 entities in total) |
機能のキーワード | 5, 6, 7, 8-tetrahydrofolate; 7, 8-dihydrofolate, hydride shift, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
由来する生物種 | Klebsiella pneumoniae CG43 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 19886.94 |
構造登録者 | |
主引用文献 | Lamb, K.M.,Lombardo, M.N.,Alverson, J.,Priestley, N.D.,Wright, D.L.,Anderson, A.C. Crystal Structures of Klebsiella pneumoniae Dihydrofolate Reductase Bound to Propargyl-Linked Antifolates Reveal Features for Potency and Selectivity. Antimicrob.Agents Chemother., 58:7484-7491, 2014 Cited by PubMed: 25288083DOI: 10.1128/AAC.03555-14 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.76 Å) |
構造検証レポート
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