4OON

Crystal structure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid)

4OON の概要

• エントリーDOI: 10.2210/pdb4oon/pdb
• 関連するPDBエントリー: 4OOL 4OOM
• 分子名称: Penicillin-binding protein 1A, (4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid (3 entities in total)
• 機能のキーワード: pbp1a, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Pseudomonas aeruginosa PAO1
• 細胞内の位置: Cell inner membrane; Single-pass type II membrane protein (By similarity): Q07806
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 89044.30

構造登録者

Han, S.,Caspers, N.,Knafels, J.D. (登録日: 2014-02-03, 公開日: 2014-05-07, 最終更新日: 2024-03-06)

• 主引用文献: Starr, J.,Brown, M.F.,Aschenbrenner, L.,Caspers, N.,Che, Y.,Gerstenberger, B.S.,Huband, M.,Knafels, J.D.,Lemmon, M.M.,Li, C.,McCurdy, S.P.,McElroy, E.,Rauckhorst, M.R.,Tomaras, A.P.,Young, J.A.,Zaniewski, R.P.,Shanmugasundaram, V.,Han, S.; Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria.; J.Med.Chem., 57:3845-3855, 2014; PubMed: 24694215; DOI: 10.1021/jm500219c

実験手法

X-RAY DIFFRACTION (3.2 Å)