4OOE
M. tuberculosis 1-deoxy-d-xylulose-5-phosphate reductoisomerase W203Y mutant bound to fosmidomycin and NADPH
Summary for 4OOE
Entry DOI | 10.2210/pdb4ooe/pdb |
Related | 3ZHX 4AIC 4OOF |
Descriptor | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID, MANGANESE (II) ION, ... (5 entities in total) |
Functional Keywords | reductoisomerase, oxidoreductase-antibiotic complex, oxidoreductase/antibiotic |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 4 |
Total formula weight | 173709.35 |
Authors | Allen, C.L.,Kholodar, S.A.,Murkin, A.S.,Gulick, A.M. (deposition date: 2014-01-31, release date: 2014-06-18, Last modification date: 2023-09-20) |
Primary citation | Kholodar, S.A.,Tombline, G.,Liu, J.,Tan, Z.,Allen, C.L.,Gulick, A.M.,Murkin, A.S. Alteration of the Flexible Loop in 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase Boosts Enthalpy-Driven Inhibition by Fosmidomycin. Biochemistry, 53:3423-3431, 2014 Cited by PubMed: 24825256DOI: 10.1021/bi5004074 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.826 Å) |
Structure validation
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