4ONT

Ternary host recognition complex of complement factor H, C3d, and sialic acid

4ONT の概要

• エントリーDOI: 10.2210/pdb4ont/pdb
• 分子名称: Complement factor H, Complement C3d fragment, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: complement control protein, ccp, short consensus repeat, scr, sushi domain, complement regulation, sialic acid, host glycan, host cell surface, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P08603 P01024
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 153200.01

構造登録者

Blaum, B.S.,Stehle, T.S. (登録日: 2014-01-29, 公開日: 2014-11-26, 最終更新日: 2023-09-20)

• 主引用文献: Blaum, B.S.,Hannan, J.P.,Herbert, A.P.,Kavanagh, D.,Uhrin, D.,Stehle, T.; Structural basis for sialic acid-mediated self-recognition by complement factor H.; Nat.Chem.Biol., 11:77-82, 2015; PubMed: 25402769; DOI: 10.1038/nchembio.1696

実験手法

X-RAY DIFFRACTION (2.15 Å)