4OLI

The pseudokinase/kinase protein from JAK-family member TYK2

Summary for 4OLI

Entry DOI	10.2210/pdb4oli/pdb
Descriptor	Non-receptor tyrosine-protein kinase TYK2, 2-chloro-N-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide (3 entities in total)
Functional Keywords	protein kinase, phospho-transfer, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	73935.73
Authors	Eigenbrot, C.,Ultsch, M.,Wallweber, H. (deposition date: 2014-01-23, release date: 2014-05-28, Last modification date: 2023-09-20)
Primary citation	Lupardus, P.J.,Ultsch, M.,Wallweber, H.,Bir Kohli, P.,Johnson, A.R.,Eigenbrot, C. Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition. Proc.Natl.Acad.Sci.USA, 111:8025-8030, 2014 Cited by PubMed: 24843152 DOI: 10.1073/pnas.1401180111 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation