4OKG

LpxC from P.aeruginosa with the inhibitor 6-(benzimidazol-1-yl)-5-[4-[2-[6-[(4-methylpiperazin-1-yl)methyl]-3-pyridyl]ethynyl]phenyl]pyridine-3-carbohydroxamic acid

4OKG の概要

• エントリーDOI: 10.2210/pdb4okg/pdb
• 分子名称: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, 6-(1H-benzimidazol-1-yl)-N-hydroxy-5-[4-({6-[(4-methylpiperazin-1-yl)methyl]pyridin-3-yl}ethynyl)phenyl]pyridine-3-carboxamide, ... (4 entities in total)
• 機能のキーワード: hydroxamate, beta-alpha-alpha-beta sandwich, deacetylase, intracellular; cytoplasm, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Pseudomonas aeruginosa
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 67511.29

構造登録者

Olivier, N.B.,Lahiri, S.D.,Prince, D.B. (登録日: 2014-01-22, 公開日: 2014-09-24, 最終更新日: 2024-02-28)

• 主引用文献: Gao, N.,McLeod, S.M.,Hajec, H.,Lahiri, S.D.,Prince, D.B.,Thresher, J.,Whiteaker, J.,Ross, P.,Olivier, N.B.,Doig, P.; Overexpression of Pseudomonas aeruginosa LpxC in the Presence of an Inhibitor in an acrB Deletion Escherichia coli strain for Structural Studies; Protein Express.Purif., 2014

実験手法

X-RAY DIFFRACTION (2.06 Å)