4OIV

Structural basis for small molecule NDB as a selective antagonist of FXR

4OIV の概要

• エントリーDOI: 10.2210/pdb4oiv/pdb
• 分子名称: Bile acid receptor, N-benzyl-N-(3-tert-butyl-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino)benzamide (3 entities in total)
• 機能のキーワード: bile acid sensor, nuclear, nuclear protein receptor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : Q96RI1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 53967.60

構造登録者

Xu, X.,Chen, L.,Hu, L.,Shen, X. (登録日: 2014-01-20, 公開日: 2015-03-25, 最終更新日: 2023-11-08)

• 主引用文献: Xu, X.,Xu, X.,Liu, P.,Zhu, Z.Y.,Chen, J.,Fu, H.A.,Chen, L.L.,Hu, L.H.,Shen, X.; Structural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor alpha (FXR alpha ) in Stabilizing the Homodimerization of the Receptor.; J.Biol.Chem., 290:19888-19899, 2015; PubMed: 26100621; DOI: 10.1074/jbc.M114.630475

実験手法

X-RAY DIFFRACTION (1.7 Å)