4OIR

Crystal structure of Thermus thermophilus RNA polymerase transcription initiation complex soaked with GE23077 and rifamycin SV

4OIR の概要

• エントリーDOI: 10.2210/pdb4oir/pdb
• 関連するPDBエントリー: 4OIN 4OIO 4OIP 4OIQ
• 関連するBIRD辞書のPRD_ID: PRD_001181
• 分子名称: DNA-directed RNA polymerase subunit alpha, rifamycin SV, ZINC ION, ... (13 entities in total)
• 機能のキーワード: ge23077, transcription inhibitor, transcription open complex, transcription initiation complex, rifamycin sv, i site, i+1 site, rna polymerase, dna/rna/ntp binding, polymerization of ribonucleotides, nucleoid, transcription, transferase-antibiotic complex, transferase/antibiotic
• 由来する生物種: Thermus thermophilus; 詳細
• 細胞内の位置: Cytoplasm (By similarity): Q5SKW1
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 443163.39

構造登録者

Zhang, Y.,Ebright, R.H.,Arnold, E. (登録日: 2014-01-20, 公開日: 2014-05-07, 最終更新日: 2023-09-20)

• 主引用文献: Zhang, Y.,Degen, D.,Ho, M.X.,Sineva, E.,Ebright, K.Y.,Ebright, Y.W.,Mekler, V.,Vahedian-Movahed, H.,Feng, Y.,Yin, R.,Tuske, S.,Irschik, H.,Jansen, R.,Maffioli, S.,Donadio, S.,Arnold, E.,Ebright, R.H.; GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.; Elife, 3:e02450-e02450, 2014; PubMed: 24755292

実験手法

X-RAY DIFFRACTION (3.105 Å)