4OIR
Crystal structure of Thermus thermophilus RNA polymerase transcription initiation complex soaked with GE23077 and rifamycin SV
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0034062 | molecular_function | 5'-3' RNA polymerase activity |
| A | 0046983 | molecular_function | protein dimerization activity |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0034062 | molecular_function | 5'-3' RNA polymerase activity |
| B | 0046983 | molecular_function | protein dimerization activity |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| C | 0006351 | biological_process | DNA-templated transcription |
| C | 0032549 | molecular_function | ribonucleoside binding |
| C | 0034062 | molecular_function | 5'-3' RNA polymerase activity |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0006351 | biological_process | DNA-templated transcription |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0034062 | molecular_function | 5'-3' RNA polymerase activity |
| E | 0003677 | molecular_function | DNA binding |
| E | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| E | 0006351 | biological_process | DNA-templated transcription |
| E | 0034062 | molecular_function | 5'-3' RNA polymerase activity |
| F | 0003677 | molecular_function | DNA binding |
| F | 0003700 | molecular_function | DNA-binding transcription factor activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006352 | biological_process | DNA-templated transcription initiation |
| F | 0006355 | biological_process | regulation of DNA-templated transcription |
| F | 0010468 | biological_process | regulation of gene expression |
| F | 0016987 | molecular_function | sigma factor activity |
| F | 2000142 | biological_process | regulation of DNA-templated transcription initiation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 401 |
| Chain | Residue |
| B | GLU154 |
| B | ASP168 |
| D | LYS840 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE RFV C 1201 |
| Chain | Residue |
| C | ARG409 |
| C | SER411 |
| C | ARG420 |
| C | ASN448 |
| C | ILE452 |
| F | ASP323 |
| C | GLN390 |
| C | SER392 |
| C | GLN393 |
| C | PHE394 |
| C | ARG405 |
| C | HIS406 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 2001 |
| Chain | Residue |
| D | CYS1112 |
| D | CYS1194 |
| D | CYS1201 |
| D | CYS1204 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 2002 |
| Chain | Residue |
| D | CYS58 |
| D | CYS60 |
| D | CYS73 |
| D | CYS76 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG D 2003 |
| Chain | Residue |
| D | ASP739 |
| D | ASP741 |
| D | ASP743 |
| D | HOH2104 |
| D | HOH2105 |
| D | HOH2106 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG D 2004 |
| Chain | Residue |
| D | TRP897 |
| D | ILE900 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG F 2001 |
| Chain | Residue |
| F | ALA292 |
| F | GLY296 |
| F | TRP299 |
| site_id | AC8 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR GE23077 |
| Chain | Residue |
| A | THR54 |
| A | ARG146 |
| A | ILE158 |
| A | PHE171 |
| B | ALA8 |
| B | PRO9 |
| B | GLU29 |
| B | ARG189 |
| C | GLU445 |
| C | GLY446 |
| C | ARG557 |
| C | MET560 |
| C | ASN563 |
| C | GLN567 |
| C | LYS838 |
| C | LYS846 |
| D | HOH2107 |
| G | DG17 |
Functional Information from PROSITE/UniProt
| site_id | PS00716 |
| Number of Residues | 27 |
| Details | SIGMA70_2 Sigma-70 factors family signature 2. TleEVGaffgVTrerIrQIEnkaLrkL |
| Chain | Residue | Details |
| F | THR382-LEU408 |
| site_id | PS00867 |
| Number of Residues | 8 |
| Details | CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. LIEANLRL |
| Chain | Residue | Details |
| F | LEU187-LEU194 |
| site_id | PS01166 |
| Number of Residues | 13 |
| Details | RNA_POL_BETA RNA polymerases beta chain signature. GdKLANrHGNKGV |
| Chain | Residue | Details |
| C | GLY836-VAL848 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 11 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
