Summary for 4OI8
Entry DOI | 10.2210/pdb4oi8/pdb |
Related | 4OI7 |
Descriptor | Advanced glycosylation end product-specific receptor, 5'-D(*CP*CP*AP*TP*GP*AP*CP*TP*GP*TP*AP*GP*GP*AP*AP*AP*CP*TP*CP*TP*AP*GP*A)-3', 5'-D(*CP*TP*CP*TP*AP*GP*AP*GP*TP*TP*TP*CP*CP*TP*AP*CP*AP*GP*TP*CP*AP*TP*G)-3', ... (4 entities in total) |
Functional Keywords | ig fold, dna binding, transport protein, signaling protein-dna complex, signaling protein/dna |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: Q15109 |
Total number of polymer chains | 4 |
Total formula weight | 62471.29 |
Authors | |
Primary citation | Sirois, C.M.,Jin, T.,Miller, A.L.,Bertheloot, D.,Nakamura, H.,Horvath, G.L.,Mian, A.,Jiang, J.,Schrum, J.,Bossaller, L.,Pelka, K.,Garbi, N.,Brewah, Y.,Tian, J.,Chang, C.,Chowdhury, P.S.,Sims, G.P.,Kolbeck, R.,Coyle, A.J.,Humbles, A.A.,Xiao, T.S.,Latz, E. RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA. J.Exp.Med., 210:2447-2463, 2013 Cited by PubMed Abstract: Recognition of DNA and RNA molecules derived from pathogens or self-antigen is one way the mammalian immune system senses infection and tissue damage. Activation of immune signaling receptors by nucleic acids is controlled by limiting the access of DNA and RNA to intracellular receptors, but the mechanisms by which endosome-resident receptors encounter nucleic acids from the extracellular space are largely undefined. In this study, we show that the receptor for advanced glycation end-products (RAGE) promoted DNA uptake into endosomes and lowered the immune recognition threshold for the activation of Toll-like receptor 9, the principal DNA-recognizing transmembrane signaling receptor. Structural analysis of RAGE-DNA complexes indicated that DNA interacted with dimers of the outermost RAGE extracellular domains, and could induce formation of higher-order receptor complexes. Furthermore, mice deficient in RAGE were unable to mount a typical inflammatory response to DNA in the lung, indicating that RAGE is important for the detection of nucleic acids in vivo. PubMed: 24081950DOI: 10.1084/jem.20120201 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.101 Å) |
Structure validation
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