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4OI8

RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA.

Replaces:  3S59
Summary for 4OI8
Entry DOI10.2210/pdb4oi8/pdb
Related4OI7
DescriptorAdvanced glycosylation end product-specific receptor, 5'-D(*CP*CP*AP*TP*GP*AP*CP*TP*GP*TP*AP*GP*GP*AP*AP*AP*CP*TP*CP*TP*AP*GP*A)-3', 5'-D(*CP*TP*CP*TP*AP*GP*AP*GP*TP*TP*TP*CP*CP*TP*AP*CP*AP*GP*TP*CP*AP*TP*G)-3', ... (4 entities in total)
Functional Keywordsig fold, dna binding, transport protein, signaling protein-dna complex, signaling protein/dna
Biological sourceHomo sapiens (human)
Cellular locationIsoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: Q15109
Total number of polymer chains4
Total formula weight62471.29
Authors
Jin, T.,Jiang, J.,Xiao, T. (deposition date: 2014-01-19, release date: 2014-04-30, Last modification date: 2024-10-16)
Primary citationSirois, C.M.,Jin, T.,Miller, A.L.,Bertheloot, D.,Nakamura, H.,Horvath, G.L.,Mian, A.,Jiang, J.,Schrum, J.,Bossaller, L.,Pelka, K.,Garbi, N.,Brewah, Y.,Tian, J.,Chang, C.,Chowdhury, P.S.,Sims, G.P.,Kolbeck, R.,Coyle, A.J.,Humbles, A.A.,Xiao, T.S.,Latz, E.
RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA.
J.Exp.Med., 210:2447-2463, 2013
Cited by
PubMed Abstract: Recognition of DNA and RNA molecules derived from pathogens or self-antigen is one way the mammalian immune system senses infection and tissue damage. Activation of immune signaling receptors by nucleic acids is controlled by limiting the access of DNA and RNA to intracellular receptors, but the mechanisms by which endosome-resident receptors encounter nucleic acids from the extracellular space are largely undefined. In this study, we show that the receptor for advanced glycation end-products (RAGE) promoted DNA uptake into endosomes and lowered the immune recognition threshold for the activation of Toll-like receptor 9, the principal DNA-recognizing transmembrane signaling receptor. Structural analysis of RAGE-DNA complexes indicated that DNA interacted with dimers of the outermost RAGE extracellular domains, and could induce formation of higher-order receptor complexes. Furthermore, mice deficient in RAGE were unable to mount a typical inflammatory response to DNA in the lung, indicating that RAGE is important for the detection of nucleic acids in vivo.
PubMed: 24081950
DOI: 10.1084/jem.20120201
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.101 Å)
Structure validation

239803

数据于2025-08-06公开中

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