4OGB

Crystal structure of the catalytic domain of PDE4D2 with compound 2

4OGB の概要

• エントリーDOI: 10.2210/pdb4ogb/pdb
• 関連するPDBエントリー: 1PTW 3SL3 3SL4 3SL5 3SL6 3SL8
• 分子名称: cAMP-specific 3',5'-cyclic phosphodiesterase 4D, (2R)-8-(3,4-dimethoxyphenyl)-6-methyl-2-(tetrahydro-2H-pyran-4-yl)-2H-chromen-4-ol, 1,2-ETHANEDIOL, ... (8 entities in total)
• 機能のキーワード: catalytic mechanism, camp hydrolysis, hydrolase-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Apical cell membrane : Q08499
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 171266.38

構造登録者

Feil, S.C.,Parker, M.W. (登録日: 2014-01-15, 公開日: 2015-01-21, 最終更新日: 2024-02-28)

• 主引用文献: Howard, B.L.,Nankervis, J.L.,Feil, S.C.,Manallack, D.T.,Holien, J.K.,Zhen, Z.,Jennings, I.G.,Abbott, B.M.,Parker, M.W.,Thompson, P.E.; The PDE inhibition profile of LY294002 and tetrahydropyranyl analogues reveals a chromone motif for the development of PDE inhibitors; To be Published,

実験手法

X-RAY DIFFRACTION (2.032 Å)