4OG5
Human menin with bound inhibitor MIV-5
Summary for 4OG5
Entry DOI | 10.2210/pdb4og5/pdb |
Related | 4OG3 4OG4 4OG6 4OG7 4OG8 |
Descriptor | Menin, 4-(3-{4-[(S)-cyclopentyl(hydroxy)pyridin-2-ylmethyl]piperidin-1-yl}propoxy)benzonitrile, SULFATE ION, ... (8 entities in total) |
Functional Keywords | protein binding-inhibitor complex, protein binding/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O00255 |
Total number of polymer chains | 1 |
Total formula weight | 55014.93 |
Authors | He, S.,Senter, T.J.,Pollock, J.W.,Han, C.,Upadhyay, S.K.,Purohit, T.,Gogliotti, R.D.,Lindsley, C.W.,Cierpicki, T.,Stauffer, S.R.,Grembecka, J. (deposition date: 2014-01-15, release date: 2014-03-05, Last modification date: 2023-09-20) |
Primary citation | He, S.,Senter, T.J.,Pollock, J.,Han, C.,Upadhyay, S.K.,Purohit, T.,Gogliotti, R.D.,Lindsley, C.W.,Cierpicki, T.,Stauffer, S.R.,Grembecka, J. High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein-Protein Interaction. J.Med.Chem., 57:1543-1556, 2014 Cited by PubMed: 24472025DOI: 10.1021/jm401868d PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.63 Å) |
Structure validation
Download full validation report